Laure Guenin-Macé Selected Research

mycolactone

1/2021	Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone.
12/2020	Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.
11/2017	Mycolactone displays anti-inflammatory effects on the nervous system.
12/2015	Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease.
5/2015	Shaping mycolactone for therapeutic use against inflammatory disorders.
9/2014	Synthetic variants of mycolactone bind and activate Wiskott-Aldrich syndrome proteins.
4/2013	Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.
12/2011	A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins.
7/2011	Mycolactone diffuses into the peripheral blood of Buruli ulcer patients--implications for diagnosis and disease monitoring.
2/2010	Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events.

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Laure Guenin-Macé Research Topics

Disease

7	Buruli Ulcer 01/2021 - 02/2010
5	Ulcer 05/2015 - 12/2009
4	Infections 12/2021 - 12/2015
3	Wiskott-Aldrich Syndrome 05/2015 - 04/2013
2	Skin Diseases (Skin Disease) 12/2011 - 02/2010
1	Inflammation (Inflammations) 10/2020
1	Hidradenitis Suppurativa 10/2020
1	Neuroinflammatory Diseases 11/2017
1	Chronic Pain 11/2017
1	Rupture 04/2013

Drug/Important Bio-Agent (IBA)

10	mycolactoneIBA 01/2021 - 02/2010
5	LipidsIBA 01/2021 - 02/2010
4	MacrolidesIBA 12/2015 - 07/2011
3	Proteins (Proteins, Gene)FDA Link 05/2015 - 04/2013
2	CytokinesIBA 11/2017 - 12/2009
1	Arachidonic Acid (Vitamin F)IBA 12/2021
1	Fatty Acids (Saturated Fatty Acids)IBA 12/2021
1	EicosanoidsIBA 12/2021
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 10/2020
1	IndolesIBA 10/2020
1	Tryptophan (L-Tryptophan)FDA Link 10/2020
1	HexosesIBA 12/2015
1	Blood Glucose (Blood Sugar)IBA 12/2015
1	Angiotensin IIIBA 05/2015
1	SolventsIBA 07/2011
1	Anti-Bacterial Agents (Antibiotics)IBA 07/2011
1	PolyketidesIBA 07/2011
1	Immunosuppressive Agents (Immunosuppressants)IBA 02/2010
1	Cytotoxins (Cytolysins)IBA 12/2009
1	mycolactone AIBA 12/2009
1	ChemokinesIBA 12/2009

Therapy/Procedure

1	Analgesia 05/2015
1	Therapeutics 07/2011